{"id":151,"date":"2019-04-24T12:53:15","date_gmt":"2019-04-24T12:53:15","guid":{"rendered":"https:\/\/sepia2.unil.ch\/pharmacology\/?page_id=151"},"modified":"2019-07-02T08:26:38","modified_gmt":"2019-07-02T08:26:38","slug":"physiological-model","status":"publish","type":"page","link":"https:\/\/sepia2.unil.ch\/pharmacology\/profiles\/physiological-model\/","title":{"rendered":"Physiological Model"},"content":{"rendered":"\n

“Model describing drug absorption, distribution and elimination in the body which is represented as a series of organs or tissue spaces” <\/h2>\n\n\n\n

Description<\/h3>\n\n\n\n

This model concentrates on the discription of \ndrug fate in the body considering observed physiological variables (body\n composition, organ anatomical volumes, flow rates of circulating body \nfluids and the fuction of the organs involved) and plasma or eventually \ntissue drug concentrations.\n<\/p>\n\n\n\n

In this model, the drug concentration profile \nresults from the uptake and elimination capacity of organs composing the\n body. The distribution<\/a>\n of the drug to an organ depends on the blood flow to the organ, the \norgan size and the partition coefficient of the drug between blood and \nthe organ. The elimination capacity depends on the drug and the organ \ninvolved. The overall drug concentration profile results from the sum of\n the processing of the drug by different organs.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Clinical implications<\/h3>\n\n\n\n

The physiological approach allows prediction of \nthe change in drug outcome due to alteration of organ fuction (e.g. \nenzymatic activity) blood flow or protein binding. Therefore, the effect\n of diseases and pharmacokinetic drug-drug interactions, due to \nphysiological and pathological changes, on the overall drug disposition \ncan be predicted.\n<\/p>\n\n\n\n

The main utility of this class of models is the \nextrapolation of drug experimental findings from animals to humans. It \nis also used in the study of local drug kinetics, most importantly for \ndrugs that have a particular site of action (e.g. drugs acting on \ntumors).<\/p>\n","protected":false},"excerpt":{"rendered":"

“Model describing drug absorption, distribution and elimination in the body which is represented as a series of organs or tissue spaces” Description This model concentrates on the discription of drug fate in the body considering observed physiological variables (body composition, organ anatomical volumes, flow rates of circulating body fluids and the fuction of the organs … <\/p>\n

Continue reading “Physiological Model”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-151","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/comments?post=151"}],"version-history":[{"count":4,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/151\/revisions"}],"predecessor-version":[{"id":620,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/151\/revisions\/620"}],"up":[{"embeddable":true,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/media?parent=151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}