{"id":219,"date":"2019-04-24T15:14:40","date_gmt":"2019-04-24T15:14:40","guid":{"rendered":"https:\/\/sepia2.unil.ch\/pharmacology\/?page_id=219"},"modified":"2020-09-04T04:34:10","modified_gmt":"2020-09-04T04:34:10","slug":"vancomycin","status":"publish","type":"page","link":"https:\/\/sepia2.unil.ch\/pharmacology\/drugs\/vancomycin\/","title":{"rendered":"Vancomycin"},"content":{"rendered":"\n<h4 class=\"inTable wp-block-heading\"> Vancomycin pharmacokinetic parameters <\/h4>\n\n\n\n<table class=\"wp-block-table has-fixed-layout\"><tbody><tr><td>Oral bioavailability (F)<\/td><td>0<\/td><\/tr><tr><td>Clearance (CL) <\/td><td>7 L\/H<\/td><\/tr><tr><td>Volume of distribution (Vd)<\/td><td>35 L<\/td><\/tr><tr><td>Half-life (t1\/2)<\/td><td>3.5 h<\/td><\/tr><\/tbody><\/table>\n\n\n\n<h3 class=\"wp-block-heading\">Description<\/h3>\n\n\n\n<p>Vancomycin is a glycopeptide antibiotic that is \nmainly used for the treatment of infections by methicillin-resistant \nstaphylococcus infections<br><br>Vancomycin is poorly absorbed after \noral administration. For parenteral therapy, the drug should be \nadministered intravenously. The drug appears in various body fluids; its\n apparent <a href=\"\/pharmacology\/volumeofdistribution.\">volume of distribution<\/a> is ~35l and about 30% of vancomycin is bound to plasma protein.&nbsp; &nbsp;<br>About 90% of an injected dose is excreted by glomerular filtration. Vancomycin has a <a href=\"\/pharmacology\/halflife.\">half-life<\/a> of approximately 3.5 h.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Clinical implications<\/h3>\n\n\n\n<p>For a successful therapy, it is important to \nachieve serum concentrations at some multiple above the minimum \ninhibitory concentration for the offending organisms and at the same \ntime to avoid potential adverse effects such as ototoxicity and \nnephrotoxicity. Vancomycine is either administered as repeated \nshort-duration (1h) infusions or as a continuous constant rate infusion.\n For repeated administration, trough plasma vancomycin concentrations \nshould be at least 5-10 mg\/ for non-complicated infections and 10-15 \nmg\/l for infections by methicillin-resistant staphylococci. For \ncontinuous administration, the steady-state serum concentration should \nbe 15-20 mg\/l for non-complicated infections and up to 25 mg\/l for \npatients with severe infections.\n<\/p>\n\n\n\n<p>In practice, therapeutic drug monitoring \n(measurement of drug plasma concentration and adaptation of dosage) of \nthe vancomycin therapy is used for patients at the intensive care unit \nor for patients with severe infections. <br>The drug accumulates if renal function is impaired, and dosage adjustments must be made under these circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vancomycin pharmacokinetic parameters Oral bioavailability (F) 0 Clearance (CL) 7 L\/H Volume of distribution (Vd) 35 L Half-life (t1\/2) 3.5 h Description Vancomycin is a glycopeptide antibiotic that is mainly used for the treatment of infections by methicillin-resistant staphylococcus infections Vancomycin is poorly absorbed after oral administration. For parenteral therapy, the drug should be administered &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/sepia2.unil.ch\/pharmacology\/drugs\/vancomycin\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Vancomycin&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":10,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-219","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/comments?post=219"}],"version-history":[{"count":4,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/219\/revisions"}],"predecessor-version":[{"id":1362,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/219\/revisions\/1362"}],"up":[{"embeddable":true,"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/pages\/10"}],"wp:attachment":[{"href":"https:\/\/sepia2.unil.ch\/pharmacology\/wp-json\/wp\/v2\/media?parent=219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}